Cording Following Treatment for Breast Cancer
Identifieur interne : 003757 ( Main/Exploration ); précédent : 003756; suivant : 003758Cording Following Treatment for Breast Cancer
Auteurs : Jean O Oole ; Cynthia L. Miller ; Michelle C. Specht ; Melissa N. Skolny ; Lauren S. Jammallo ; Nora Horick ; Krista Elliott ; Andrzej Niemierko ; Alphonse G. TaghianSource :
- Breast cancer research and treatment [ 0167-6806 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Aisselle (anatomopathologie), Analyse multivariée, Autorapport, Bras (physiopathologie), Complications postopératoires (anatomopathologie), Complications postopératoires (épidémiologie), Facteurs de risque, Femelle, Humains, Lymphoedème (anatomopathologie), Lymphoedème (étiologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein (), Tumeurs du sein (anatomopathologie), Études de cohortes.
- MESH :
- anatomopathologie : Aisselle, Complications postopératoires, Lymphoedème, Tumeurs du sein.
- physiopathologie : Bras.
- épidémiologie : Complications postopératoires.
- étiologie : Lymphoedème.
- Adulte, Adulte d'âge moyen, Analyse multivariée, Autorapport, Facteurs de risque, Femelle, Humains, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein, Études de cohortes.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Arm (physiopathology), Axilla (pathology), Breast Neoplasms (pathology), Breast Neoplasms (surgery), Cohort Studies, Female, Humans, Lymphedema (etiology), Lymphedema (pathology), Middle Aged, Multivariate Analysis, Postoperative Complications (epidemiology), Postoperative Complications (pathology), Risk Factors, Self Report.
- MESH :
- epidemiology : Postoperative Complications.
- etiology : Lymphedema.
- pathology : Axilla, Breast Neoplasms, Lymphedema, Postoperative Complications.
- physiopathology : Arm.
- surgery : Breast Neoplasms.
- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Middle Aged, Multivariate Analysis, Risk Factors, Self Report.
Abstract
Treatment for breast cancer may result in the formation of palpable cords in the axillary region. Our aim was to evaluate cording incidence, risk factors, and association with upper extremity functional impairment and measured arm volume change.
We included 308 patients with unilateral breast cancer prospectively screened for upper extremity lymphedema, symptoms and function. Patients were assessed pre- and post-operatively and at 3 – 8 month intervals with perometer arm measurements and the LEFT-BC questionnaire. Cording was determined by patient self-report. The cumulative incidence of cording and its association with clinicopathologic factors, upper extremity functional impairment, and measured arm volume change were analyzed.
31.5% (97/308) of patients reported cording, with a cumulative incidence of 36.2% at 24 months post-operative. Clinicopathologic factors significantly associated with cording by multivariate analysis included axillary lymph node dissection (p<.0001) and younger age at diagnosis (p=0.0005). Cording was associated with increased functional impairment (p=0.0018) and an arm volume increase of ≥5% (p=0.028).
Cording following breast cancer treatment is common, and may occur beyond the post-operative period. Our findings emphasize the importance of identifying patients at high risk for cording, and developing strategies to minimize functional impairment and arm volume elevation associated with cording. Future studies should investigate the effectiveness of interventions for cording following breast cancer treatment.
Url:
DOI: 10.1007/s10549-013-2616-9
PubMed: 23813304
PubMed Central: 3786257
Affiliations:
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Miller</name><affiliation><nlm:aff id="A2">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Specht, Michelle C" sort="Specht, Michelle C" uniqKey="Specht M" first="Michelle C" last="Specht">Michelle C. Specht</name><affiliation><nlm:aff id="A3">Division of Surgical Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Skolny, Melissa N" sort="Skolny, Melissa N" uniqKey="Skolny M" first="Melissa N" last="Skolny">Melissa N. Skolny</name><affiliation><nlm:aff id="A2">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Jammallo, Lauren S" sort="Jammallo, Lauren S" uniqKey="Jammallo L" first="Lauren S" last="Jammallo">Lauren S. Jammallo</name><affiliation><nlm:aff id="A2">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Horick, Nora" sort="Horick, Nora" uniqKey="Horick N" first="Nora" last="Horick">Nora Horick</name><affiliation><nlm:aff id="A4">Department of Biostatistics, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Elliott, Krista" sort="Elliott, Krista" uniqKey="Elliott K" first="Krista" last="Elliott">Krista Elliott</name><affiliation><nlm:aff id="A3">Division of Surgical Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Niemierko, Andrzej" sort="Niemierko, Andrzej" uniqKey="Niemierko A" first="Andrzej" last="Niemierko">Andrzej Niemierko</name><affiliation><nlm:aff id="A2">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author><author><name sortKey="Taghian, Alphonse G" sort="Taghian, Alphonse G" uniqKey="Taghian A" first="Alphonse G" last="Taghian">Alphonse G. Taghian</name><affiliation><nlm:aff id="A2">Department of Radiation Oncology, Massachusetts General Hospital</nlm:aff><wicri:noCountry code="subfield">Massachusetts General Hospital</wicri:noCountry></affiliation></author></analytic><series><title level="j">Breast cancer research and treatment</title><idno type="ISSN">0167-6806</idno><idno type="eISSN">1573-7217</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Arm (physiopathology)</term><term>Axilla (pathology)</term><term>Breast Neoplasms (pathology)</term><term>Breast Neoplasms (surgery)</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Lymphedema (etiology)</term><term>Lymphedema (pathology)</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Postoperative Complications (epidemiology)</term><term>Postoperative Complications (pathology)</term><term>Risk Factors</term><term>Self Report</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Aisselle (anatomopathologie)</term><term>Analyse multivariée</term><term>Autorapport</term><term>Bras (physiopathologie)</term><term>Complications postopératoires (anatomopathologie)</term><term>Complications postopératoires (épidémiologie)</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (étiologie)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein ()</term><term>Tumeurs du sein (anatomopathologie)</term><term>Études de cohortes</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Aisselle</term><term>Complications postopératoires</term><term>Lymphoedème</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Axilla</term><term>Breast Neoplasms</term><term>Lymphedema</term><term>Postoperative Complications</term></keywords><keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Bras</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Arm</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Complications postopératoires</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Multivariate Analysis</term><term>Risk Factors</term><term>Self Report</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse multivariée</term><term>Autorapport</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein</term><term>Études de cohortes</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Treatment for breast cancer may result in the formation of palpable cords in the axillary region. Our aim was to evaluate cording incidence, risk factors, and association with upper extremity functional impairment and measured arm volume change.</p></sec><sec id="S2"><title>Methods</title><p id="P2">We included 308 patients with unilateral breast cancer prospectively screened for upper extremity lymphedema, symptoms and function. Patients were assessed pre- and post-operatively and at 3 – 8 month intervals with perometer arm measurements and the LEFT-BC questionnaire. Cording was determined by patient self-report. The cumulative incidence of cording and its association with clinicopathologic factors, upper extremity functional impairment, and measured arm volume change were analyzed.</p></sec><sec id="S3"><title>Results</title><p id="P3">31.5% (97/308) of patients reported cording, with a cumulative incidence of 36.2% at 24 months post-operative. Clinicopathologic factors significantly associated with cording by multivariate analysis included axillary lymph node dissection (p<.0001) and younger age at diagnosis (p=0.0005). Cording was associated with increased functional impairment (p=0.0018) and an arm volume increase of ≥5% (p=0.028).</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Cording following breast cancer treatment is common, and may occur beyond the post-operative period. Our findings emphasize the importance of identifying patients at high risk for cording, and developing strategies to minimize functional impairment and arm volume elevation associated with cording. Future studies should investigate the effectiveness of interventions for cording following breast cancer treatment.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Elliott, Krista" sort="Elliott, Krista" uniqKey="Elliott K" first="Krista" last="Elliott">Krista Elliott</name><name sortKey="Horick, Nora" sort="Horick, Nora" uniqKey="Horick N" first="Nora" last="Horick">Nora Horick</name><name sortKey="Jammallo, Lauren S" sort="Jammallo, Lauren S" uniqKey="Jammallo L" first="Lauren S" last="Jammallo">Lauren S. Jammallo</name><name sortKey="Miller, Cynthia L" sort="Miller, Cynthia L" uniqKey="Miller C" first="Cynthia L" last="Miller">Cynthia L. Miller</name><name sortKey="Niemierko, Andrzej" sort="Niemierko, Andrzej" uniqKey="Niemierko A" first="Andrzej" last="Niemierko">Andrzej Niemierko</name><name sortKey="O Oole, Jean" sort="O Oole, Jean" uniqKey="O Oole J" first="Jean" last="O Oole">Jean O Oole</name><name sortKey="Skolny, Melissa N" sort="Skolny, Melissa N" uniqKey="Skolny M" first="Melissa N" last="Skolny">Melissa N. Skolny</name><name sortKey="Specht, Michelle C" sort="Specht, Michelle C" uniqKey="Specht M" first="Michelle C" last="Specht">Michelle C. Specht</name><name sortKey="Taghian, Alphonse G" sort="Taghian, Alphonse G" uniqKey="Taghian A" first="Alphonse G" last="Taghian">Alphonse G. Taghian</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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